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  Indian J Med Microbiol
 

Figure 9: (a-e) Classical HL: A 32-year-old man with 2 × 2 cm left cervical lymphadenopathy. FNA cytodiagnosis: CHL-MC, ICC results: CD30+, CD15+, LCA–, CD20–, and EMA–. Histopathological diagnosis: CHL-NS. (a) Many large mononucleated Hodgkin cells among mature lymphocytes (Pap × 400). (b) A large tetranucleated Reed-Sternberg cell among lymphocytes (Pap × 400). (c) A large binucleated Reed-Sternberg cell and an eosinophil (MGG × 1000). (d) Hodgkin and Reed-Sternberg (HRS). HRS cells are positive for CD30 (×1000). (e) HRS cells are positive for CD15 (×1000). (f-h) Nodular lymphocytic predominant Hodgkin lymphoma (NLPHL): A 28-year-old man 2 × 2 cm left cervical lymph node. FNA and histopathological diagnosis: NLPHL. IHC of RS cells: LCA+, CD20+, CD79a+, EMA+, CD3–, CD57–, CD68–, Ki67+, HLA-DR+, CD15–, CD30–, CD21–, CD23–, and EBV–. (f) “Popcorn” type of RS cell with lobulated nucleus surrounded by lymphocytes (MGG × 1000). (g) Two “popcorn” types of RS cells partly surrounded by lymphocytes (Pap × 1000). (h) One RS cell with positive reaction for CD20 (×400)

Figure 9: (a-e) Classical HL: A 32-year-old man with 2 × 2 cm left cervical lymphadenopathy. FNA cytodiagnosis: CHL-MC, ICC results: CD30+, CD15+, LCA–, CD20–, and EMA–. Histopathological diagnosis: CHL-NS. (a) Many large mononucleated Hodgkin cells among mature lymphocytes (Pap × 400). (b) A large tetranucleated Reed-Sternberg cell among lymphocytes (Pap × 400). (c) A large binucleated Reed-Sternberg cell and an eosinophil (MGG × 1000). (d) Hodgkin and Reed-Sternberg (HRS). HRS cells are positive for CD30 (×1000). (e) HRS cells are positive for CD15 (×1000). (f-h) Nodular lymphocytic predominant Hodgkin lymphoma (NLPHL): A 28-year-old man 2 × 2 cm left cervical lymph node. FNA and histopathological diagnosis: NLPHL. IHC of RS cells: LCA+, CD20+, CD79a+, EMA+, CD3–, CD57–, CD68–, Ki67+, HLA-DR+, CD15–, CD30–, CD21–, CD23–, and EBV–. (f) “Popcorn” type of RS cell with lobulated nucleus surrounded by lymphocytes (MGG × 1000). (g) Two “popcorn” types of RS cells partly surrounded by lymphocytes (Pap × 1000). (h) One RS cell with positive reaction for CD20 (×400)