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  Indian J Med Microbiol
 

Figure 8: Anaplastic large cell lymphoma (ALCL): A 52-year-old man had an 8 × 10 cm chest wall mass on right side. FNA cytodiagnosis: ALCL. ICC findings: LCA+, CD30+, CD15–, CD20–, CD3–, EMA+, Akl1+, CK–, and HMB45–. Histopathological diagnosis: ALCL. IHC: CD45+, CD30+, EMA+, CD2+, CD3+, CD4+, CD5+, CD7+, CD25+, CD43+, Alk1+, and Ki67+ (90% cells). (a) Very large and pleomorphic lymphoma cells (Pap × 1000). (b, c). The lymphoma cells had intracytoplasmic hyaline globules (arrows) (b: Pap × 1000, and c: MGG × 1000). (d) The lymphoma cells were positive for CD30 (×1000). (e) The lymphoma cells including hyaline globule (arrow) are positive for EMA (×1000). (f) The lymphoma cells showed weak positive reaction for Alk1 (×1000). (g) Positive reaction of lymphoma cells to LCA in cell block preparation (×1000). (h) Positive reaction of lymphoma cells to CD3 (×1000)

Figure 8: Anaplastic large cell lymphoma (ALCL): A 52-year-old man had an 8 × 10 cm chest wall mass on right side. FNA cytodiagnosis: ALCL. ICC findings: LCA+, CD30+, CD15–, CD20–, CD3–, EMA+, Akl1+, CK–, and HMB45–. Histopathological diagnosis: ALCL. IHC: CD45+, CD30+, EMA+, CD2+, CD3+, CD4+, CD5+, CD7+, CD25+, CD43+, Alk1+, and Ki67+ (90% cells). (a) Very large and pleomorphic lymphoma cells (Pap × 1000). (b, c). The lymphoma cells had intracytoplasmic hyaline globules (arrows) (b: Pap × 1000, and c: MGG × 1000). (d) The lymphoma cells were positive for CD30 (×1000). (e) The lymphoma cells including hyaline globule (arrow) are positive for EMA (×1000). (f) The lymphoma cells showed weak positive reaction for Alk1 (×1000). (g) Positive reaction of lymphoma cells to LCA in cell block preparation (×1000). (h) Positive reaction of lymphoma cells to CD3 (×1000)