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  Indian J Med Microbiol
 

Figure 2: T-cell prolymphocytic leukemia (T-PLL): A 92-year-old man presented with generalized lymphadenopathy. FNA cytodiagnosis: CLL. Total leukocyte count was 26 × 109/L. Direct smear was CD20–, CD23–, and CD3+. Cell block preparation: CD3+, CD4+, CD5+, CD7+, CD20–, CD8–, and Tdt–. (a) FNA smear from cervical lymph node shows small monomorphic neoplastic lymphoid cells, slightly larger than mature lymphocytes with scanty cytoplasm and small nucleoli (MGG × 1000). (b) FNA smears from axillary lymph node shows lymphoid cells with coarse chromatin and small nucleoli, some of them with hand-mirror configuration (Pap × 1000). (c) Cervical lymph node: occasional tumor cells were positive for CD20 (×1000). (d) axillary lymph node: most tumor cells were positive for CD3 (×1000). (e) Peripheral smear: small lymphocyte with lobulated/irregular nuclei (MGG × 1000). (f-h): Cell block of left cervical lymph node FNA showing positive reactions for (f): CD3 (×1000), (f): CD5 (×1000), and (h): CD7 (×1000)

Figure 2: T-cell prolymphocytic leukemia (T-PLL): A 92-year-old man presented with generalized lymphadenopathy. FNA cytodiagnosis: CLL. Total leukocyte count was 26 × 10<sup>9</sup>/L. Direct smear was CD20–, CD23–, and CD3+. Cell block preparation: CD3+, CD4+, CD5+, CD7+, CD20–, CD8–, and Tdt–. (a) FNA smear from cervical lymph node shows small monomorphic neoplastic lymphoid cells, slightly larger than mature lymphocytes with scanty cytoplasm and small nucleoli (MGG × 1000). (b) FNA smears from axillary lymph node shows lymphoid cells with coarse chromatin and small nucleoli, some of them with hand-mirror configuration (Pap × 1000). (c) Cervical lymph node: occasional tumor cells were positive for CD20 (×1000). (d) axillary lymph node: most tumor cells were positive for CD3 (×1000). (e) Peripheral smear: small lymphocyte with lobulated/irregular nuclei (MGG × 1000). (f-h): Cell block of left cervical lymph node FNA showing positive reactions for (f): CD3 (×1000), (f): CD5 (×1000), and (h): CD7 (×1000)