Journal of Cytology

ORIGINAL ARTICLE
Year
: 2022  |  Volume : 39  |  Issue : 3  |  Page : 105--109

Cytological diagnosis of malignant mesothelioma: A case series


Sakshi Dahiya, Meeta Singh, Shyama Jain, Bembem Khuraijam, Naman Suroya, Shramana Mandal 
 Department of Pathology, Maulana Azad Medical College, Delhi, India

Correspondence Address:
Dr. Meeta Singh
Department of Pathology, Room No-206, Pathology Block, Maulana Azad Medical College, New Delhi - 110 002
India

Background: Mesotheliomas are neoplasms of the serosal lining of the body cavities. Diagnosis requires a multimodal approach of clinical findings, cytology, and histopathology with immunohistochemistry (IHC). The published sensitivity of cytology for diagnosing mesothelioma ranges from 30% to 75%. Aim and Objectives: This study aimed to calculate the incidence of malignant mesothelioma (MM) at our institute and to study the cytological features of MM. Materials and Methods: A retrospective study of pleural, peritoneal, and pericardial fluids submitted at our institute was done. The duration of the study was 8 years (2011–2019). Apart from examining Giemsa smears, a panel of immunocytochemical (ICC) and cell block immunohistochemical (IHC) markers was applied to achieve the diagnosis. These included calretinin, mesothelin, CK5/6, Hector Battifora mesothelial cell antibody (HBME), WT1, MOC31, CK7 and CK20. Histopathological correlation was done wherever possible. Result: In the present study, we compiled four cases of MM over 8 years diagnosed on serous effusion cytology and confirmed by immunocytochemistry (ICC)/cell block immunohistochemistry (IHC)/biopsy. This indicates a rare incidence of MM. The Cytological features of MM were studied. Conclusion: The diagnosis of MM is difficult, especially cytologically. It was found to be a rare entity in the malignant cases diagnosed on effusion cytology.


How to cite this article:
Dahiya S, Singh M, Jain S, Khuraijam B, Suroya N, Mandal S. Cytological diagnosis of malignant mesothelioma: A case series.J Cytol 2022;39:105-109


How to cite this URL:
Dahiya S, Singh M, Jain S, Khuraijam B, Suroya N, Mandal S. Cytological diagnosis of malignant mesothelioma: A case series. J Cytol [serial online] 2022 [cited 2022 Oct 1 ];39:105-109
Available from: https://www.jcytol.org/article.asp?issn=0970-9371;year=2022;volume=39;issue=3;spage=105;epage=109;aulast=Dahiya;type=0