Journal of Cytology
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Year : 2022  |  Volume : 39  |  Issue : 3  |  Page : 134-136

Diagnosis of lung adenocarcinoma with clear cell features in pleural effusion: Cytomorphologic features, immunocytochemical studies, and differential diagnosis

1 Cytopathology Division, Department of Pathology, Prof. Dr. Cemil Tascioglu City Hospital, İstanbul, Turkey
2 Department of Pathology, Siirt Training and Research Hospital, Siirt, Turkey
3 Department of Pathology, Basaksehir Cam and Sakura City Hospital, İstanbul, Turkey

Correspondence Address:
Dr. Senay Erdogan-Durmus
Cytopathology Division, Department of Pathology, Prof. Dr. Cemil Tascioglu City Hospital, İstanbul
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/joc.joc_48_22

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Clear cell adenocarcinoma (CCA) of the lungs is no longer referred to as a subtype in recent classifications of lung adenocarcinoma. Like signet ring features, clear cell features are regarded as cytological features rather than histological subtypes. Additionally, in serous fluids, adenocarcinoma metastasis with clear cell features is a diagnostic challenging entity due to other tumors that come to mind first during the differential diagnosis. Here we report a case, diagnosed as CCA of lung metastasis in pleural fluid and evaluated its differential diagnosis.

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