Journal of Cytology
Home About us Ahead of print Instructions Submission Subscribe Advertise Contact e-Alerts Login 
Users Online:677
  Print this page  Email this page Small font sizeDefault font sizeIncrease font size
ORIGINAL ARTICLE
Year : 2016  |  Volume : 33  |  Issue : 4  |  Page : 214-219

Thyroid FNAC containing hürthle cells and hürthle-like cells: A study of 128 cases


1 Department of Pathology, Ankara Ataturk Research and Training Hospital, Ankara, Turkey
2 Department of Pathology, Faculty of Medicine, Yildirim Beyazit University, Ankara, Turkey
3 Department of General Surgery, Guven Hospital, Ankara, Turkey
4 Department of Endocrinology and Metabolism, Faculty of Medicine, Kahramanmaras Sutcu Imam University, Kahramanmaras, Turkey
5 Department of Endocrinology and Metabolism, Faculty of Medicine, Yildirim Beyazit University, Ankara, Turkey
6 Department of Pathology, Ankara Oncology Hospital, Ankara, Turkey
7 Department of Pathology, Faculty of Medicine, Hacettepe University, Ankara, Turkey

Correspondence Address:
Dr. Aylin Yazgan
Ankara Ataturk Research and Training Hospital, Bilkent Yolu No: 3, Bilkent Ankara
Turkey
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0970-9371.190447

Rights and Permissions

Aim: It is a diagnostic challenge to differentiate benign and malignant cytology in the presence of Hürthle cells. In our previous study, it was determined that in fine needle aspirations (FNA), the malignancy outcome of the Hürthle cells containing group tend to be papillary thyroid carcinoma (PTC) in a higher percentage. The most common misinterpretation is caused by PTC cells with large cytoplasm-like Hürthle cells. The aim of this study is to predict histologic outcome of the nodules, which have Hürthle cells in FNA according to cytological, clinical features, and BRAF V600Emutation status. Materials and Methods: Detailed cytological features of 128 cases were compared with histopathological diagnosis. The analysis of BRAF V600Emutation of the PTC cases were performed by real-time polymerase chain reaction. Results: The neoplastic outcome was increased statistically significantly with younger age (P = 0.020), increase in cellular dyshesion (P = 0.016), presence of nuclear budding (P = 0.046), and granular chromatin (P = 0.003). Nuclear budding (P = 0.014), granular chromatin (P = 0.012), and hypoechoic nodules in ultrasonography (P = 0.011) were significant independent factors for the increase in the malignancy risk. Increased lymphocytes (P= 0.015) and colloid were related to non-neoplastic outcome. According to the surgical outcome, more than half of the malign cases were PTC (74%). BRAF V600Emutation was detected in 27.8% of the PTC cases. Conclusion: PTC cases containing Hürthle cell-like cells may lead to diagnostic errors. Nuclear budding and granular chromatin of Hürthle cells are significant, remarkable findings to predict the outcome of neoplasm and malignancy.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed6208    
    Printed58    
    Emailed0    
    PDF Downloaded330    
    Comments [Add]    
    Cited by others 2    

Recommend this journal