Journal of Cytology
Home About us Ahead of print Instructions Submission Subscribe Advertise Contact e-Alerts Login 
Users Online:519
  Print this page  Email this page Small font sizeDefault font sizeIncrease font size
Year : 2008  |  Volume : 25  |  Issue : 4  |  Page : 138-143

Cells in pleural fluid and their value in differential diagnosis

1 Safdarjung Hospital, New Delhi, India
2 Department of Pathology, S.S.I.M.R.S. Davangere, India
3 J.J.M. Medical College, Davangere, India

Correspondence Address:
Rashmi Kushwaha
H. No. F 130/4, Second Floor, Gautam Nagar, New Delhi 110 049
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0970-9371.50799

Rights and Permissions

Background : Both non-malignant and malignant causes of effusion can be identified by the relatively non-invasive technique of pleural fluid cytology. With this basis the present study on cytology of pleural fluids was taken up. The diagnostic significance of the cytologic study of the fluid may be attributable to the fact that the cell population present in the sediment is representative of a much larger surface area than that obtained by needle biopsy. Materials and Methods : One hundred samples of pleural fluid were examined for total cell count, cell type and cellular features. They were also subjected to biochemical study to find out the level of protein, glucose and chloride. Results : A total of 82% samples were exudative and 18% were transudative. Total leukocyte count (TLC) was less than 1000 cells/ in most (88.89%) of transudative effusions. Overall 52.44% of exudative effusions had TLC greater than 1000 cells/ It was noted that 96.88% of tuberculous effusions had more than 50% lymphocytes, 81.25% had protein greater than 5 gm/dl and 90.63% had glucose greater than 60 mg/dl. Approximately 28% of pleural effusions were positive for malignant cells. Most (82%) of malignant effusions were exudative. The primary site could be assessed by cytological examination in 57.14% of malignant effusions. Conclusions: The most useful test in establishing the diagnosis of pleural effusion is pleural fluid cytology and pleural fluid cell count. Cytologic study of pleural fluid is a complete diagnostic modality which aims at pointing out the etiology of effusion as well as, in certain cases, a means of prognostication of disease process.

Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded2158    
    Comments [Add]    
    Cited by others 19    

Recommend this journal