Journal of Cytology
Home About us Ahead of print Instructions Submission Subscribe Advertise Contact e-Alerts Login 
Users Online:546
  Print this page  Email this page Small font sizeDefault font sizeIncrease font size
Year : 2008  |  Volume : 25  |  Issue : 1  |  Page : 18-22

Role of AgNORs in thyroid lesions on fine needle aspiration cytology smears

Department of Pathology, Indira Gandhi Medical College, Shimla, India

Correspondence Address:
Sarita Asotra
Flat No-5, Block No-5, Phase-III, New Shimla - 171 009, Himachal Pradesh
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0970-9371.40653

Rights and Permissions

Background: Fine needle aspiration has an important role in diagnosis of thyroid neoplasm. However, it is difficult to differentiate between follicular adenoma and follicular carcinoma by cytology alone. Recently, silver staining has been performed for nucleolar organizer regions (AgNORs) to differentiate various tumors. Aims: The present study was undertaken to see if the AgNOR technique could distinguish between benign and malignant lesions, particularly, follicular neoplasm. Materials and Methods: One hundred forty cases of thyroid lesions were examined, which included colloid goiter (n = 36), multinodular goiter (n = 38), subacute thyroiditis (n = 6), Hashimoto's thyroiditis (n = 17), lymphocytic thyroiditis (n = 3), follicular neoplasm (n = 18), Hurthle cell neoplasm (n = 3), papillary carcinoma (n = 16), and medullary carcinoma (n = 3). Diagnosis was confirmed by histopathology in 80 cases. The usual one-step silver colloidal reaction was performed at room temperature for 35 minutes and intranuclear dots of silver deposits were counted in 100 cells. Results: AgNOR counts of benign and malignant lesions were compared and were found to be statistically significant (P < 0.001). The mean AgNOR counts were higher in neoplastic lesions. Conclusions: AgNOR counting in fine needle aspiration smears is a simple, sensitive, and cost-effective method for differentiating benign from malignant thyroid follicular neoplasms.

Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded451    
    Comments [Add]    
    Cited by others 7    

Recommend this journal