Journal of Cytology
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Year : 2005  |  Volume : 22  |  Issue : 4  |  Page : 165-170

Cytomorphology of anaplastic thyroid carcinoma - A study of 35 cases

Associate Professor, Department of Pathology, Government Medical College, Nagpur, India

Correspondence Address:
A Deshpande
377, Shankarnagar, Nagpur, Maharashtra - 440 010
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Source of Support: None, Conflict of Interest: None

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Thirty five cases of anaplastic thyroid carcinoma (ATC) were studied by fine needle aspiration cytology. Pleomorphic, round cell, spindle cell and paucicellular type were detected on cytology. It is worthwhile repeating the aspiration twice or thrice if the initial aspiration is inadequate because this often yields adequate diagnostic material and is of value in inoperable tumours which may be treated with radiotherapy or chemotherapy alone after a cytologic diagnosis. Histologic correlation was obtained in 29 patients. ATC has to be distinguished from medullary carcinoma, lymphoma, haemangioendothelioma and primary sarcomas of the thyroid. All patients were treated with a combination of surgery, radiotherapy and chemotherapy but showed a rapid downhill course and died within a period of two years. Preoperative diagnosis is important because these tumours need aggressive therapy. ATC remains an aggressive tumour that responds poorly to therapy.

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