Journal of Cytology
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Year : 2005  |  Volume : 22  |  Issue : 3  |  Page : 137-139

Pseudomyxoma peritonei - Signet ring cell type diagnosed by ascitic fluid cytology

1 Consultant pathologist and HOD, pathology department, Medwin hospitals, Hyderabad, India
2 Junior pathologist, Medwin hospitals, Hyderabad, India

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A Sudha
Srigiri, 16-11-16/M/38, East Prashant Nagar, Hyderabad, Andhara Pradesh - 500 036
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Source of Support: None, Conflict of Interest: None

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Pseudomyxoma peritonei is defined as peritoneal involvement by a mucinous neoplasm accompanied by collections of intraabdominal mucus (mucinous ascites). Cytologic examination of ascitic fluid, which is usually a thick and gelatinous material may appear to be devoid of cells except for an occasional macrophage. However, if enough fluid is examined, it is possible to find tumor cells with varying cytologic appearances ranging from benign mucinous epithelium to poorly differentiated adenocarcinoma based on the histology of the primary neoplasm. We studied ascitic fluid in a patient whose main complaint was rapidly increasing ascites unresponsive to antituberculous treatment.There were whorls of signet ring cells in a background of abundant mucin. A diagnosis of pseudomyxoma peritonei was followed by a peritoneal biopsy which confirmed a signet ring cell carcinoma. Colonoscopy and subsequent biopsy of caecal ulcer revealed primary tumor in the caecum.

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