Journal of Cytology
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Year : 2003  |  Volume : 20  |  Issue : 4  |  Page : 177-179

AgNOR counts in exfoliative cytology smears of preinvasive and invasive squamous epithelial lesions of cervix

1 Associate professor, Department of Pathology, Lady Hardinge Medical College, New Delhi, India
2 Professor, Department of Pathology, Lady Hardinge Medical College, New Delhi, India

Correspondence Address:
Sangeeta Pahuja
C-90, Naraina Vihar, New Delhi - 110028
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Source of Support: None, Conflict of Interest: None

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Nucleolar organiser regions (NORs) are chromosomal segments coding for ribosomal RNA. Number of NORs correlates with cellular proliferation and has diagnostic and prognostic value in neoplastic diseases. The study was conducted to evaluate the utility of AgNOR counting in cytology smears of various grades of squamous intraepithelial and invasive lesions of cervix. AgNOR staining was done on 30 cases of preinvasive and invasive malignant epithelial lesions of cervix. AgNOR dots were counted in at least 100 dyskaryotic/malignant cells with the help of camera lucida drawings and mean AgNOR number/nucleus was calculated. We observed that mean AgNOR/nucleus increased with increasing grade of lesion with statistically significant difference between HGSIL and SCC of cervix. Hence AgNORs can be helpful to differentiate preinvasive from invasive squamous epithelial lesions of cervix.

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