Journal of Cytology
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Year : 2000  |  Volume : 17  |  Issue : 3  |  Page : 149-153

Cytomorphologic variations in nephroblastoma

1 Professor, Department of Pathology, Lady Hardinge Medical College, New Delhi, India
2 Senior Resident, Department of Pathology Lady Hardinge Medical College, New Delhi, India
3 Associate Professor, Department of Surgery, Lady Hardinge Medical College, New Delhi, India

Correspondence Address:
Manjula Jain
Professor, Department of Pathology, Lady Hardinge Medical College, New Delhi
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Source of Support: None, Conflict of Interest: None

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Cytomorphological findings in six cases of Nephrobiastoma are described. All the three elements-blastemal, epithelial and stromal-described on histopathology were encountered in varying proportions depending upon differentiation. Blastemal component was seen as small round to oval cells with scanty cytoplasm and fine nuclear chromatin. Epithelial component was identified as rossette-like arrangement of blastemal cells and the presence of glomeruloid bodies. Stromal component was seen as spindle shaped cells with smooth muscle and skeletal muscle differentiation in one case each. These findings correlated well with the findings on histopathology as well as with immunohistochemistry. FNA is advocated as a safe and accurate procedure for the pre-operative diagnosis for chemotherapeutic protocols in Nephroblastoma.

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