Journal of Cytology
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ORIGINAL ARTICLE
Year : 1999  |  Volume : 16  |  Issue : 1  |  Page : 27-36

Fine needle aspiration cytology of liver : An analysis of 530 cases

NA Jambhekar1, R Saxena2, S Krishnamurthy1, R Bharadwaj3, A Sheth4
1 Consultant Histopathologist, Department of Pathology, Tata Memorial Hospital, Mumbai, India
2 Ex-Research Fellow, Department of Pathology, Tata Memorial Hospital, Mumbai, India
3 Oncopathology Trainee, Department of Pathology, Tata Memorial Hospital, Mumbai, India
4 Resident Pathologist, Department of Pathology, Tata Memorial Hospital, Mumbai, India

Correspondence Address:
N A Jambhekar
Department of Pathology, 8th Floor, Annexe Building, Tata Memorial Hospital, Dr. Ernest Borges Road, Parel, Mumbai - 400 012
India
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Source of Support: None, Conflict of Interest: None


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This is a two year study of 530 liver aspirates that included 40 benign and292malignanttumours. Smears from hepatocellular carcinomas were cellular and showed a complex ramifying "Staghorn" pattern. Nodular aggregates covered by endothelium and projecting within sinusoids were characteristic. Smears of cirrhosis showed smaller fragments with loosely arranged hepatocytes. Cytological variation within single cell clusters was seen in contrast to uniform atypia within a single cell cluster in hepatocellular carcinoma. Metastatic tumours showed interspersed clusters of normal hepatocytes and cytological features specific to the primary tumour. The commonest metastatic tumour was gastrointestinal adenocarcinoma. In 16cases, it was impossible to differentiate the primary or the metastatic nature of the tumour. In 16 cases, it was difficult to pinpoint the source of the metastasis. The general diagnostic yield of FNAC was 62.6% whereas that of guided FNAC was 53.8%. We attribute the latter to small sample size and the fact that guided FNAC was reserved for inaccessible, deep seated lesions and sometimes doubtful lesions.


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