Journal of Cytology
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Year : 1998  |  Volume : 15  |  Issue : 1  |  Page : 31-38

Immunocytochemical analysis of poorly differentiated tumors on fine needle aspiration cytology material

Department of Cytology, Postgraduate Institute of Medical Education and Research, Chandigarh 160 012, India

Correspondence Address:
Arvind Rajwanshi
Additional Professor of Cytology, Dept. of Cytology, PGIMER, Additional Professor of Cytology, Dept. of Cytology, PGIMER, Chandigarh 160 012
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Source of Support: None, Conflict of Interest: None

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One hundred cases of poorly differentiated tumors were studied by immunocytochemical staining on fine needle aspiration smears by indirect immunoperoxidase technique using monoclonal antibodies to cytokeratin (CK), vimentin (VIM), leucocyte common antigen (LCA), neuron specific enolase (NSE), and desmin (DES) to see the utility of immunocytochemistry in the routine diagnostic work-up of poorly differentiated tumors. Eighty seven percent of carcinomas were positive for CK. Small cell carcinomas formed a heterogenous group with 50.0% cases positive for both CK and NSE and 16.6% positive for NSE alone. Co-expression of CK and VIM was seen in 4 carcinomas. Seventy five percent of lymphomas showed positivity with LCA. VIM was positive in 72.7% sarcomas. After immunostaining a conclusive result could be obtained in 74 % of the cases. Immunostaining was least useful in the categorisation of soft tissue sarcomas and most useful in the diagnosis of round cell tumors (RCT) where it was helpful in arriving at a diagnosis in 61% cases.

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