Journal of Cytology
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Year : 1997  |  Volume : 14  |  Issue : 1  |  Page : 31-34

Interobserver variability and diagnostic significance of agnor counts in fine needle aspiration cytology smears of breast lesions

Department of Pathology, King George's Medical College, Lucknow-226 003, India

Correspondence Address:
P K Agarwal
A-15, Nirala Nagar, Lucknow U.P. 226020, India
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Source of Support: None, Conflict of Interest: None

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The object of the present study was to determine the interobserver variability and limits of agretement in the enumeration of AgNOR counts and to differentiate benign from malignant lesions of breast For this work, air dried FNA smears from thirty five cases (27 malignant and 8 benign) of breast lumps were taken for AgNOR counts. The total mean AgNOR dots (mAgNOR) and proliferation index (pAgNOR) were counted by two different observers. The interobserver variation for both the observers were 4% to 9% for mean AgNOR counts and 6% to 12% for pAgNOR counts. The total number of mean AgNOR counts exceeded in malignant tumours (6.705 ± 0.906) than those of benign tumours (1.538 ± 0.374). These values were statistically significant (p0.0002). FNA smears present superior staining and better dispersion of AgNOR black dots in nucleoli as compared to paraffin sections.

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