Cervical carcinogenesis and hormonal contraceptives
JS Misra, K Das
Dept. of Obstetrics & Gynaecology, KG Medical College, Lucknow, India
J S Misra Dept. of Obstetrics & Gynaecology, K.G. Medical College, Lucknow India
Source of Support: None, Conflict of Interest: None
Cytological evaluation of cervical smears was carried out in 1843 women receiving 5 different progestational preparations used as contraceptives for periods ranging from 6 months to 5 years to ascertain theironcogenic potential following long term use. No case of cervical carcinoma was found even after 4-5 years of hormone treatment but cervical dysplasia was seen in 44 cases (2.4%). Follow-up of 33 of the 44 cases with dysplasia while still on contraceptives and 20 cases with dysplasia present prior to treatment showed regression of lesion either spontaneously or after specific medication. The comparative cytological data suggests that norplants are the safest choice for long term use upto 5 years as far as their oncogenic potential is concerned.