Journal of Cytology
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Year : 1995  |  Volume : 12  |  Issue : 1  |  Page : 29-33

Cytohistopathological study of helicobacter pylori in endoscopic biopsies

1 Upgraded Department of Pathology, King George's Medical College, Lucknow, India
2 Upgraded Department of Gastro entrology, King George's Medical College, Lucknow, India

Correspondence Address:
Padam K Agrawal
A-15, Nirala Nagar, Lucknow
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Source of Support: None, Conflict of Interest: None

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Eighty eight Endoscopic gastric biopsies, 180 imprint and 190 brush smears from eighty eight patients clinically suspected to have acid pepsin disease were reviewed and compared for presence of Helicobacter pylori. Histologic diagnosis of these cases were; chronic gastritis (55), gastric carcinoma (7), and normal gastric mucosa (26). Besides routine haematoxylin and eosin stain on smears and sections, half Gram stain was done to demonstrate H. pylori. The organisms could be identified cytologically in 98% brush smears and 89% imprint smears when these were present in corresponding biopsy specimens. The overall diagnostic accuracy, sensitivity and specificity of brush cytology was 98% as compared to that of 91%, 80% and 97% respectively of imprint cytology. The organisms were not found in cases of gastric carcinomas and intestinal metaplasia. The study highlights the efficacy of brush cytology in detection of H.pylori which is a rapid and reliable method and is better than imprint cytology.

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